Value of gamma-glutamyltranspeptidase-to-platelet ratio in diagnosis of hepatic fibrosis in patients with chronic hepatitis B

Table 4 GPR, APRI, and FIB-4 results relative to hepatic fibrosis stage (F1, F2, F3, and F4) in CHB patients

	Parameter	GPR	APRI	FIB-4	GPR + APRI (in parallel)	GPR + APRI (in series)	GPR + FIB-4 (in parallel)	GPR + FIB-4 (in series)
	AUC	0.723	0.581	0.612	-	-	-	-
	Cut-off	0.448	0.166	0.201	-	-	-	-
F1	Sensitivity	90.6%	88.8%	62.1%	88.8%	86.8%	80.2%	83.6%
	Specificity	54.2%	87.5%	66.3%	87.5%	90.2%	89%	87.9%
	AUC	0.741	0.706	0.711	-	-	-	-
	Cut-off	0.402	0.361	0.4	-	-	-	-
F2	Sensitivity	57.1%	75.8%	47.4%	72.7%	78.4%	65%	76.8%
	Specificity	89.5%	92.5%	89.3%	89.7%	96%	89%	96.6%
	AUC	0.826	0.73	0.751	-	-	-	-
	Cut-off	0.548	0.496	0.44	-	-	-	-
F3	Sensitivity	74.1%	70.6%	64.7%	81.3%	78.6%	70.3%	72.7%
	Specificity	91.8%	90.5%	88%	98.6%	97.4%	98.5%	98%
	AUC	0.833	0.799	0.778	-	-	-	-
	Cut-off	0.591	0.538	0.503	-	-	-	-
F4	Sensitivity	83.2%	74%	75.4%	80%	73.2%	78.8%	74.4%
	Specificity	96.5%	95.4%	94.5%	97.4%	97.9%	96.8%	97.7%

In parallel: Both parameters are met simultaneously; In series: One of two parameters is met.