Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine

doi:10.3748/wjg.v23.i41.7369

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World Journal of Gastroenterology

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World J Gastroenterol. Nov 7, 2017; 23(41): 7369-7386
Published online Nov 7, 2017. doi: 10.3748/wjg.v23.i41.7369

Table 2 Seven upregulated proteins with no DE mRNA targeted by 15 downregulated miRNAs

Protein					microRNA
Uniprot	Symbol	Title	Linear FC	Adj. P value	miRBase ID	logFC	LinFC	AveExpr	P Value	Adj. P value

O43852	CALU	Calumenin	1.86	0.0162	hsa-let-7a	-1.44	-2.72	12.58	1.30E-04	0.00396
					hsa-let-7b	-2.61	-6.11	12.84	1.71E-06	0.00017
					hsa-let-7c	-3.45	-10.94	11.26	2.39E-06	0.00021
					hsa-let-7d	-2.66	-6.34	12.12	2.20E-06	0.00020
					hsa-let-7e	-1.40	-2.65	12.39	6.41E-05	0.00236
					hsa-let-7f	-2.85	-7.20	8.75	5.04E-06	0.00034
					hsa-let-7g	-1.06	-2.08	8.90	2.99E-04	0.00737
					hsa-let-7i	-2.31	-4.95	10.22	2.35E-06	0.00021
					hsa-miR-29a	-1.63	-3.09	9.69	1.14E-04	0.00361
					hsa-miR-200a	-2.68	-6.43	9.16	4.14E-04	0.00965
					hsa-miR-200b	-2.54	-5.81	10.40	2.63E-05	0.00129
P20810	CAST	Calpastatin	2.39	0.00011	hsa-miR-125a-3p	-3.14	-8.83	5.84	3.26E-05	0.00150
					hsa-miR-224	-2.44	-5.42	7.35	8.21E-04	0.01667
					hsa-miR-375	-4.06	-16.67	8.29	1.50E-05	0.00083
P21333	FLNA	Filamin-A	3.59	0.00048	hsa-miR-125a-3p	-3.14	-8.83	5.84	3.26E-05	0.00150
P13797	PLS3	Plastin-3	5.88	0.00006	hsa-miR-200b	-2.54	-5.81	10.40	2.63E-05	0.00129
P78330	PSPH	Phosphoserine phosphatase	2.22	0.0004	hsa-miR-200b	-2.54	-5.81	10.40	2.63E-05	0.00129
P35241	RDX	Radixin	5.57	0.00012	hsa-let-7a	-1.44	-2.72	12.58	1.30E-04	0.00396
					hsa-let-7b	-2.61	-6.11	12.84	1.71E-06	0.00017
					hsa-let-7c	-3.45	-10.94	11.26	2.39E-06	0.00021
					hsa-let-7d	-2.66	-6.34	12.12	2.20E-06	0.00020
					hsa-let-7e	-1.40	-2.65	12.39	6.41E-05	0.00236
					hsa-let-7f	-2.85	-7.20	8.75	5.04E-06	0.00034
					hsa-let-7g	-1.06	-2.08	8.90	2.99E-04	0.00737
					hsa-let-7i	-2.31	-4.95	10.22	2.35E-06	0.00021
					hsa-miR-31	-1.94	-3.83	12.79	7.91E-05	0.00274
Q13885	TUBB2A	Tubulin beta-2A chain	1.46	0.00388	hsa-miR-29a	-1.63	-3.09	9.69	1.14E-04	0.00361

Seven proteins found upregulated in the Caco-2 cell line relative to the HT-29 cell line and predicted to be targeted by 15 unique anti-correlated/downregulated microRNAs.

Citation: O’Sullivan F, Keenan J, Aherne S, O’Neill F, Clarke C, Henry M, Meleady P, Breen L, Barron N, Clynes M, Horgan K, Doolan P, Murphy R. Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine. World J Gastroenterol 2017; 23(41): 7369-7386
URL: https://www.wjgnet.com/1007-9327/full/v23/i41/7369.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i41.7369