Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model

Figure 5 Ultrastructural changes of hepatocytes. A and D: Hepatocytes of the young control group A and the aged control group D, respectively; B and E: Hepatocytes of the young group B and aged group E of UWP without metformin, respectively; C and F: Hepatocytes of the young group C and aged group F of MUWP, respectively. The black arrows indicate the nuclei, the white arrows indicate the intracellular mitochondria of the young groups, and the white triangles indicate the intracellular mitochondria of the aged groups. UWP: University of Wisconsin solution perfusion; MUWP: Metformin perfusion solution. Original magnification (A-F): ×10000.