Glucagon-like peptide-2 modulates the nitrergic neurotransmission in strips from the mouse gastric fundus

Figure 4 Influence of glucagon-like peptide-2 on the neurally-induced relaxant responses. A: Typical tracing showing the electrical field stimulation (EFS)-induced relaxant responses at different stimulation frequencies (left panel). EFS evokes fast relaxant responses, followed by a slow component at the higher stimulation frequencies (≥ 8 Hz). GLP-2 at 2 nmol/L causes (right panel) an increase in amplitude of the EFS-induced fast relaxation in whole range of stimulation frequencies employed and a decrease of the slow one; B: Bar chart of the effects of GLP-2 (glucagon-like peptide-2, 2 and 20 nmol/L) on the mean amplitude of the EFS-induced fast relaxation. Note that GLP-2 increases the amplitude of the EFS-induced fast relaxant responses in a dose-related manner. Relaxant responses are expressed as percentage decrease relative to the muscular tension induced by 1 μmol/L CCh taken as 100%. Amplitude values of EFS-induced fast relaxations refer to the maximal peak obtained during the stimulation period. All values are mean ± SE of six preparations. ^aP < 0.05 vs the ctr; ^cP < 0.05 vs the ctr and vs 2 nmol/L GLP-2 (ANOVA and Newman-Keuls post-test).