Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients

Table 3 Inflammatory bowel disease-associated single nucleotide polymorphisms associated with different type of adverse events

Adverse event	Risk allele	SNP	Gene (s) of interest	P value	OR (95%CI)
Infusion	C	rs6740462	SPRED2	0.003	0.4 (0.2-0.7)
Infusion	G	rs1182188	GNA12	0.007	1.8 (1.2-2.6)
Infusion	G	rs10061469	TMEM174, FOXD1	0.010	0.5 (0.3-0.9)
Infusion	A	rs477515	HLA-DRB1	0.010	1.7 (1.1-2.5)
Allergic	A	rs4692386	SMIM20, RBPJ	0.010	0.5 (0.3-0.9)
Allergic	A	rs10761659	ZNF365	0.010	0.6 (0.3-0.9)
Lupus-like	G	rs13407913	ADCY3	0.003	3.5 (1.6-7.9)
Lupus-like	C	rs10051722	CHSY2, HINT1	0.010	2.7 (1.2-5.7)
Rash	A	rs1363907	ERAP2	0.003	3.0 (1.5-6.2)
Rash	G	rs11010067	PARD3	0.003	0.2 (0.1-0.6)
Rash	C	rs7746082	PREP	0.005	2.7 (1.3-5.3)
Any	C	rs6740462	SPRED2	0.0007	0.6 (0.5-0.8)
Any	C	rs10774482	ERC1	0.003	1.4 (1.1-1.8)

SNP: Single nucleotide polymorphisms.