Comparative study: Vonoprazan and proton pump inhibitors in Helicobacter pylori eradication therapy

Figure 1 Helicobacter pylori eradication rates (full analysis set) for vonoprazan, esomeprazole, rabeprazole, and lansoprazole in first-line triple therapy. The eradication rate was significantly higher in the VPZ group than that in the EPZ, RPZ, and LPZ groups (^aP < 0.05); ^cP < 0.05 vs lansoprazole. VPZ 20: 20 mg VPZ, 200 mg CAM, and 750 mg AMPC twice a day for 1 wk. EPZ 20: 20 mg EPZ, 200 mg CAM, and 750 mg AMPC twice a day for 1 wk. RPZ 10: 10 mg RPZ, 200 mg CAM, and 750 mg AMPC twice a day for 1 wk. LPZ 30: 30 mg LPZ, 200 mg CAM, and 750 mg AMPC twice a day for 1 wk. VPZ: Vonoprazan; EPZ: Esomeprazole; CAM: Clarithromycin; AMPC: Amoxicillin; RPZ: Rabeprazole; LPZ: Lansoprazole; H. pylori: Helicobacter pylori.