Intraepithelial lymphocytes, scores, mimickers and challenges in diagnosing gluten-sensitive enteropathy (celiac disease)

Table 4 North American - European divergences across oceans in gluten-sensitive enteropathy

	Target	Screening	PS Tests1	HLA-DQ	EMA	AGA
ESPGHAN	Paediatric	Anti-tTG-IgA and IgA2	Anti-tTG-IgG/anti-DPG-IgG3	Yes, if	Yes, in confirming PS tests	No
				↑EMA/anti-tTG
ACG	Paediatric/adult	Anti-tTG-IgA	Anti-tTG-IgG/anti-DPG-IgG3	Yes, if biopsy/serology disagreement	NS	No
WGO	NS	Anti-tTG-IgA/anti-DPG IgG	NS	Yes, if biopsy/serology disagreement	Yes, in confirming PS tests	No

¹Postscreening tests;

²Total serum IgA;

³Anti-DPG: Anti-deamidated gliadin peptide. ESPGHA: European Society of Pediatric Gastroenterology, Hepatology and Nutrition; ACG: American College of Gastroenterology; WGO: World Gastroenterology Organization; NS: Not specified.