Evidence from a familial case suggests maternal inheritance of primary biliary cholangitis

Figure 1 Microscopic features of the patients’ liver biopsies (H&E stain, × 400). A: Patient 1: A non-necrotizing granuloma is surrounded by lymphoid infiltrates (arrow); B: Patient 2: Aggregates of lymphocytes indicate the early phase of the disease; C: Patient 3: Mild portal inflammation without bile duct damage or granuloma is present; D: Patient 4: A damaged bile duct is identified in a background of lymphocytes and plasma cells (arrow).