Optimal timing for the oral administration of Da-Cheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis

Figure 2 Da-Cheng-Qi decoction elevated IL-10 levels and lowered IL-6 levels in serum of the rats with acute pancreatitis. Rats (n = 6 per group) in the three treatment groups were orally dosed with DCQD (10 mL/kg.BW) 4 h, 12 h and 24 h after AP induction. Serum samples were collected at 24 h after a single dosage of DCQD. The results are presented as the mean ± SD. NG(b): the sham-operated group; MG(b): the model group or the control group; 4hG(b), 12hG(b) and 24hG(b): rats were orally dosed with DCQD 4 h, 12 h and 24 h, respectively, after AP induction. AP: Acute pancreatitis; DCQD: Da-Cheng-Qi decoction.