Copyright
©The Author(s) 2017.
World J Gastroenterol. Oct 21, 2017; 23(39): 7174-7184
Published online Oct 21, 2017. doi: 10.3748/wjg.v23.i39.7174
Published online Oct 21, 2017. doi: 10.3748/wjg.v23.i39.7174
Patient characteristics | Medical history | Post FMT situation | Adverse events in 1 mo | |
1 | A patient with HIV, ulcerative colitis and rCDI | 28-year-old male with HIV, antiviral medication and virus undetectable, previous suspicion of ulcerative colitis. Recurrent diarrhoea with C. difficile positivity, slow response to vancomycin. | No further relapses | No |
Two months after diarrhoea recurred at the same time with mild alcohol associated pancreatitis. In colonoscopy final diagnosis of ulcerative colitis was made. C. difficile remained negative. | ||||
2 | A patient with HIV, alcoholism and rCDI | 59-year-old female, depression, continuous heavy smoking and consumption of alcohol. HIV and antiviral therapy. rCDI after antibiotic treatment for respiratory infection. | No further relapses | No |
Diarrheal continued due to exocrine pancreatic insufficiency and excessive alcohol consumption | ||||
5 mo after FMT C. difficile reinfection treated with vancomycin and fidaxomicin | ||||
3 | A Haemodialysis patient with rCDI #1 | 60-year-old female, rheumatoid arthritis and in haemodialysis due to amyloidosis. Chronic atrial fibrillation, polypectomies of rectum adenomas. Had Enterococcus sepsis 2012. | No further relapses. | No |
Half a year after FMT Enterococcus faecalis sepsis and an epidural abscess. | ||||
4 | A Haemodialysis patient with rCDI #2 | 19-year-old female, haemodialysis due to Goodpasture syndrome complicated with pulmonary haemorrhage. Immunosuppressive therapy. | No further relapses. | No |
5 | A Haemodialysis patient with rCDI #3 | 77-year-old male, haemodialysis after renal carcinoma operation, diabetes II and COPD. Pseudomonas septicaemia followed by rCDI. | No further relapses. | One week after hospitalized due to enema and cystitis |
One week after FMT hospitalized due to generalized enema and possible cystitis. | ||||
Two months after FMT hospitalized due to gastroenteritis, faecal clostridium was negative. | ||||
6 | A Haemodialysis patient with rCDI #4 | 80-year-old male. Haemodialysis because of chronic glomerulonephritis, type II diabetes, hypertension, epilepsy, AV-block and a pace maker. Staphylococcus aureus septicaemia followed by rCDI. | No further relapses. | No |
Staphylococcus aureus sepsis 5 mo after the FMT. | ||||
7 | A Haemodialysis patient with rCDI #5 | 66-year-old male, haemodialysis due to microscopic polyangiitis. Chronic atrial fibrillation. | No further relapses | No |
8 | A Haemodialysis patient with rCDI #6 | 79-year-old female. Hypertension, dyslipidaemia, atrophic gastritis. TIA 2004 and 2005, a pace maker due to bifascicular block. Coronary disease. Haemodialysis due to an episode of rhabdomyolysis. | 2 wk after FMT reinfection after an antibiotic treatment of cystitis. No further FMT's due to poor general condition. | 2 wk after C. difficile reinfection |
Patient died 2 mo after FMT to underlying diseases | ||||
9 | A Kidney transplant patient with rCDI #1 | 78-year-old female. Kidney transplant due to polycystic renal disease. Polycystic liver, type II diabetes, hypertension and asthma. Operated for cholecystectomy and hysterectomy. E. coli sepsis and one month after another infectious episode treated with meropenem followed by severe rCDI. | No further relapses | Gastroenteritis 3 d after FMT Hospitalized 12 d after FMT |
3 d after FMT gastroenteritis, Clostridium was not tested. Restarted vancomycin for 2 d. | ||||
12 d after FMT the patient was hospitalized due to infection, CT scan did not reveal the aetiology. | ||||
10 | A Kidney transplant patient with rCDI #2 | 61-year-old female. A kidney transplant due to polycystic renal disease. rCDI after clindamycin for dental infection. | No further relapses | No |
11 | A Liver transplant patient with rCDI | 56-year-old female. Liver transplant due to mushroom intoxication, a moderate renal failure. | No further relapses | No |
12 | A Patient with a liver transplant, renal insufficiency, haemodialysis and rCDI | 69-year-old male. Liver transplantation due to alcohol cirrhosis, followed by renal insufficiency and haemodialysis. | No further relapses | No |
13 | A Patient with chronic lymphatic leukaemia, chronic norovirus infection and rCDI | 65-year-old female. Chronic lymphatic leukaemia since 1996. Autologous stem cell transplantation in 2003. Cytostatic interventions from 2009-2011, after which she had prolonged pancytopenia, infections and hypogammaglobinaemia. In summer 2011, she had chronic norovirus infection and recurrent CDI, several vancomycin courses and gammaglobulin infusions. March 2012 FMT | No primary complications | CDI and norovirus related diarrhoea continued. |
Hospitalized 2 wk after FMT due to diarrhoea. | ||||
Both norovirus and Clostridium difficile stayed positive in stool samples. | ||||
Patient died in August 2012, 5 mo after FMT for complications of her haematological disease. |
- Citation: Lahtinen P, Mattila E, Anttila VJ, Tillonen J, Teittinen M, Nevalainen P, Salminen S, Satokari R, Arkkila P. Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patients with new indications: A case series. World J Gastroenterol 2017; 23(39): 7174-7184
- URL: https://www.wjgnet.com/1007-9327/full/v23/i39/7174.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i39.7174