Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men

Table 4 Multivariate analyses to predict the presence of columnar-lined esophagus in Japanese alcoholic men

	CLE, ≥ 5 mm vs 0-4 mm
Independent variables	OR	95%CI	P value
Age, per +10 yr	1.15	(1.00-1.32)	0.043
Usual alcohol consumption, per +22 g ethanol	0.99	(0.96-1.03)	0.75
Ever smoker vs never smoker	0.75	(0.49-1.14)	0.17
Hiatal hernia ≥ 10 mm, presence vs absence	4.33	(3.31-5.67)	< 0.0001
Liver cirrhosis, presence vs absence	1.04	(0.68-1.60)	0.86
Esophageal varices, presence vs absence	0.47	(0.26-0.87)	0.015
Gastric varices, presence vs absence	0.59	(0.21-1.64)	0.31
Portal hypertensive gastropathy
Absent	1.00	Referent
Grade 1	1.23	(0.86-1.78)	0.26
Grade 2,3	0.91	(0.52-1.60)	0.74
Anti-HCV antibody, positive vs, negative	0.93	(0.53-1.66)	0.81
HBs antigen, positive vs, negative	0.56	(0.13-2.47)	0.44
ALDH2 genotype, *1/*1 vs *1/*2	0.94	(0.67-1.33)	0.73
ADH1B genotype, *2 carrier vs *1/*1	0.97	(0.73-1.28)	0.81

ADH1B: Alcohol dehydrogenase-1B; ALDH2: Aldehyde dehydrogenase-2; OR: Multivariate odds ratio; CI: Confidence interval; CLE: Columnar-lined esophagus. ORs and CIs were calculated by using a multiple logistic regression model.