Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men

Table 1 Background of the Japanese alcoholic men with and without esophageal varices n (%)

	Esophageal varices
	Absent	Present	P value
n	1434	180
Age (yr)
mean ± SE	55.8 ± 0.3	54.4 ± 0.7	0.079
Alcohol consumption (g ethanol/d)
mean ± SE	121 ± 2	133 ± 7	0.066
Ever smoker	1310 (91.4)	159 (88.3)	0.21
Liver cirrhosis
Absent	1282 (89.4)	6 (3.3)
Present	152 (10.6)	174 (96.7)	< 0.0001
Gastric Varices
Absent	1418 (98.9)	147 (81.7)
Cardia, cardia/fornix	2 (0.1)	23 (12.8)
Fornix	14 (1.0)	10 (5.6)	< 0.0001
Portal hypertensive gastropathy	1432	179
Absence	1172 (81.8)	59 (33.0)
Grade 1	191 (13.3)	80 (44.7)
Grade 2	53 (3.7)	25 (14.0)
Grade 3	16 (1.1)	15 (8.4)	< 0.0001
Anti-HCV antibody positive	69 (4.8)	13 (7.2)	0.20
HBs antigen positive	17 (1.2)	4 (2.2)	0.28
ALDH2 genotype
*1/*1	1216 (84.8)	161 (89.4)
*1/*2	218 (15.2)	19 (10.6)
*2/*2	0 (0.0)	0 (0.0)	0.12
ADH1B genotype
*1/*1	406 (28.3)	41 (22.8)
*1/*2	470 (32.8)	69 (38.3)
*2/*2	558 (38.9)	70 (38.9)	0.20

ADH1B: Alcohol dehydrogenase-1B; ALDH2: Aldehyde dehydrogenase-2; P values were calculated by Student's t-test for mean values, and Fisher's exact test for percent data.