Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study

Table 2 Clinimetric test for articular-gastrointestinal activity and patient reported outcomes of health-related quality of life

Test	Items and interpretation
Bath Ankylosing Spondylitis Disease Index[10]	6 items: (1) fatigue, (2) back pain, (3) peripheral pain/swelling, (4) discomfort at pressure, (5) morning discomfort, and (6) duration of morning stiffness;
	Range from 0 to 10, with lower number representing less severe disease activity;
	Score > 4 = active disease.
Ankylosing Spondylitis Disease Activity Score-C-Reactive Protein[11]	5 items: (1) back pain, (2) morning stiffness, (3) patient global, (4) peripheral pain/swelling, and (5) C-reactive protein;
	Score < 1.3 = inactive disease; Score 1.3 to < 2.1 = moderate activity; Score 2.1 to ≤ 3.5 = high activity; Score > 3.5 = very high activit; Change ≥ 1.1 = clinically important improvement; Change ≥ 2.0 = major improvement.
Crohn’s Disease Activity Index[12]	8 items: (1) liquid stools, (2) abdominal pain, (3) general well-being, (4) extra-intestinal manifestations (including arthralgia), (5) use of anti-diarrheals, (6) abdominal masses, and (7) hematocrit, 8) weight;
	Final score is the sum of items, weighted by different factors;
	Score < 150 = non-active disease; Score > 150 = active disease; Score > 450 = extremely severe disease.
Partial MAYO score[13]	3 items: (1) stool frequency, (2) rectal bleeding, and (3) physician global assessment;
	Range from 0 to 9;
	Score < 2 = disease remission; Score 2-4 = mild disease activity; Score 5-7 = moderate disease activity; Score > 7 = severe disease activity.
Bath Ankylosing Spondylitis Functional Index[14]	10 questions designed to determine the degree of functional limitation;
	Final score ranges from 0 to 10, with lower score indicating less functional limitation.
Inflammatory Bowel Disease Questionnaire[15]	32 questions divided into 4 subscales: (1) bowel symptoms (10 questions); (2) systemic symptoms, including sleep disorders and fatigue (5 questions); (3) emotional function, such as depression, aggression and irritation (12 questions); and (4) social function, meaning the ability to participate in social activities and to work (5 questions);
	The patient is invited to choose from 1 to 7 for every question;
	Total score ranges from 32 to 224 points, with lower scores reflecting worse quality of life.
Patient Global Assessment (PtGA)	Collected on a numeric rating scale ranging from 0 to 10 for the question asking the patient: “Considering all the ways your disease affects you, how much do you think is active today?”
Short Form-36 health survey[16]	Generic health status instrument with 8 domains: (1) physical function, (2) body pain, (3) role limitations–physical, (4) general health, (5) vitality, (6) social function, (7) role limitations–emotional, and (8) mental health;
	Greater scores reflect better health status;
	Summarized in two summary scores defined as the (1) physical component score (Sf-36/PCS) and (2) mental component score (Sf-36/MCS).