Mitofusin-2 mediated mitochondrial Ca2+ uptake 1/2 induced liver injury in rat remote ischemic perconditioning liver transplantation and alpha mouse liver-12 hypoxia cell line models

doi:10.3748/wjg.v23.i38.6995

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2017; 23(38): 6995-7008
Published online Oct 14, 2017. doi: 10.3748/wjg.v23.i38.6995

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Figure 8 Mfn2 knockdown relieves endoplasmic reticulum Ca²⁺ decrease. FLUOFORTE^® Calcium Assay and thapsigargin were used to detect ER Ca²⁺ concentrations by VarioskanFlash. Taking the hypoxia group as the reference, both the NC and hypoxia + Si groups showed higher ER Ca²⁺ concentrations. ER: Endoplasmic reticulum; Mfn2: Mitofusin-2; NC: Normal culture. ^cP < 0.001.

Citation: Liang RP, Jia JJ, Li JH, He N, Zhou YF, Jiang L, Bai T, Xie HY, Zhou L, Sun YL. Mitofusin-2 mediated mitochondrial Ca²⁺ uptake 1/2 induced liver injury in rat remote ischemic perconditioning liver transplantation and alpha mouse liver-12 hypoxia cell line models. World J Gastroenterol 2017; 23(38): 6995-7008
URL: https://www.wjgnet.com/1007-9327/full/v23/i38/6995.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i38.6995