Delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats

Figure 6 A short course of rapamycin induces antigen-specific tolerance. Allogeneic liver transplantations were performed (DA donor to LEW recipients), and the rats were treated with a short course of rapamycin (1 mg/kg, days 4 to 11). On day 30 after liver transplantation, skin grafts were performed with skin from the same DA donor or from third-party F344 rats. The control groups received allogeneic skin grafts from DA or F344 donors with rats (LEW) that did not undergo liver transplantation. A: Cumulative survival curves; days indicate the days post-skin graft, n = 3-5 rats/group; B: Representative images are shown on day 7 and day 30 after skin grafts.