Delayed and short course of rapamycin prevents organ rejection after allogeneic liver transplantation in rats

Figure 2 The protective effects of a short course of rapamycin on liver function. Fully allogeneic liver transplantation (DA donor to LEW recipient) was performed, and the rats were given no treatment or were treated with 1 mg/kg rapamycin (8-d treatment from day 4 to day 11). Total bilirubin, ALAT, and ASAT expression levels were measured in rat sera on postoperative days 11 (control vs rapamycin) and 42 (rapamycin vs syngeneic graft). The graph shows the cumulative data from 4-5 rats/group. P-values are indicated when the differences between the two groups of rats are significant (^bP ≤ 0.01, ^eP ≤ 0.001). ALAT: Alanine aminotransferase; ASAT: Aspartate aminotransferase.