Copyright
©The Author(s) 2017.
World J Gastroenterol. Oct 7, 2017; 23(37): 6750-6776
Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6750
Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6750
Figure 2 Stimuli that trigger the gain of stemness of non-cancer stem cells in hepatocellular carcinoma.
The diagram includes the conditions that are reported to induce stemness: epigenetics (histone modifications, DNA methylation, Chromatin remodeling and miRNA regulation); microenvironment that includes hypoxia, inflammation and cellular populations participation (MF, nF, CAF, lymphocytes, CSC and non-CSC, ECM, EC); epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) and chemotherapy (QX: chemotherapy insult, i.e. carboplatin, curcumina and cisplatin). MF: Miofibroblast; nF: Normal fibroblast; CAF: Cancer associated fibroblast; CSC: Cancer stem cell; ECM: Extracellular matrix; EC: Endothelial cells.
- Citation: Flores-Téllez TN, Villa-Treviño S, Piña-Vázquez C. Road to stemness in hepatocellular carcinoma. World J Gastroenterol 2017; 23(37): 6750-6776
- URL: https://www.wjgnet.com/1007-9327/full/v23/i37/6750.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i37.6750