Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features

Table 4 Genotype and allele frequency in percentage of patients with colorectal cancer and controls

Gene	dbSNP	Case/control (n = 140/140)
		Genotype frequency				Allele frequency		HWE
		II	ID	DD	P value	I	D	P value
ACE	rs4646994	21.0/14.3	49.3/54.3	29.7/31.4	0.335	45.7/41.4	54.3/58.6	0.161
CASP8	rs3834129	34.5/30.0	46.0/46.4	19.4/23.6	0.605	57.6/53.2	42.4/46.8	0.424
SGSM3	rs56228771	7.2/3.6	30.2/36.4	62.6/60.0	0.274	22.3/21.8	77.7/78.2	0.415
CYP19A1	rs11575899	35.8/37.9	49.6/50.0	14.6/12.1	0.82	60.3/62.9	39.7/37.1	0.402
CYP2E1	-	0.7/0.7	17.3/12.9	82.0/86.4	0.588	9.4/7.1	90.6/92.6	0.716
HLAG	rs371194629	14.7/13.6	43.4/50.0	41.9/36.4	0.538	36.4/38.6	63.6/61.4	0.514
IL1A	rs3783553	46.0/52.1	38.8/37.9	15.1/10.0	0.368	65.5/71.1	34.5/28.9	0.348
IL4	rs79071878	48.9/60.0	40.3/37.1	10.8/2.9	0.017	69.1/78.6	30.9/21.4	0.223
MDM2	rs3730485	50.4/50.7	43.2/37.1	6.5/12.1	0.219	71.9/69.3	28.1/30.7	0.132
NFKB1	rs28362491	38.1/40.7	46.0/42.1	15.8/17.1	0.806	61.2/61.8	38.8/38.2	0.203
TP53	rs17878362	3.6/1.4	27.3/32.1	69.1/66.4	0.383	17.3/17.5	82.7/82.5	0.181
TP53	rs17880560	7.2/7.1	39.6/32.9	53.2/60.0	0.489	27.0/23.6	73.0/76.4	0.297
TYMS	rs151264360	46.0/42.9	43.9/42.1	10.1/15.0	0.459	68.0/63.9	32.0/36.1	0.308
UCP2	-	6.6/9.3	35.3/44.3	58.1/46.4	0.149	24.3/31.4	75.7/68.6	0.745
UGT1A1	rs8175347	11.5/10.8	44.6/46.0	43.9/43.2	0.785	33.8/33.8	66.2/66.2	0.735
XRCC1	rs3213239	41.7/42.9	47.5/45.0	10.8/12.1	0.894	65.5/65.4	34.5/34.6	0.941

Genotype frequencies are presented as the percentage of patients with colorectal cancer/percentage of controls, and analysis by Chi-square test. dbSNP: Register of genetic variation on NCBI database; bp: Base pairs of DNA sequence; HWE: Hardy-Weinberg Equilibrium.