Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis

doi:10.3748/wjg.v23.i37.6802

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2017; 23(37): 6802-6816
Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6802

Table 5 Spearman correlations of ERα and ERβ expression in nuclear tissue lysates with nuclear cyclin D1 and nuclear phosphorylated NF-κB expression

	r-coefficient (P value)
	Normal	HCV	HCC
Correlations with nuclear ERα
Nuclear ERβ	0.63880 (0.0468)^a	0.63539 (0.0264)^a	0.73192 (0.0008)^b
Nuclear cyclin D1	0.12049 (0.7402)	0.75728 (0.0043)^a	0.55714 (0.0202)^a
Nuclear pNF-κB	-0.62968(0.0511)^c	0.207 (0.5186)	0.4793 (0.0516)^c
Correlations with nuclear ERβ
Nuclear cyclin D1	0.44012 (0.2031)	0.64445 (0.0237)^a	0.51223 (0.0355)^a
Nuclear pNF-κB	-0.52091 (0.1226)	0.10243 (0.7514)	0.25861 (0.3162)

^aP < 0.05,

^bP < 0.001,

^cP < 0.055. HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; ER: Estrogen receptor.

Citation: Iyer JK, Kalra M, Kaul A, Payton ME, Kaul R. Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol 2017; 23(37): 6802-6816
URL: https://www.wjgnet.com/1007-9327/full/v23/i37/6802.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i37.6802