Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis

doi:10.3748/wjg.v23.i37.6802

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2017; 23(37): 6802-6816
Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6802

Table 4 Spearman correlations of ERα and ERβ expression in whole tissue lysates with nuclear cyclin D1, nuclear phosphorylated NF-κB and cytoplasmic phosphorylated IKK expression

	R-coefficient (P value)
	Normal	HCV	HCC
Correlations with WTL ERα
ERβ	0.4154 (0.0692)	0.81944 (0.0006)^b	0.70339 (0.0107)^a
Nuclear cyclin D1	0.62189 (0.0549)	0.88842 (0.0075)^a	-0.29785 (0.3737)
Nuclear pNF-κB	0.02757 (0.9397)	0.84435 (0.0169)^a	0.19351 (0.5686)
Cytoplasmic pIKK	-0.21577 (0.5494)	-0.09787 (0.8346)	-0.37679 (0.2534)
Correlations with WTL ERβ
Nuclear cyclin D1	-0.03251 (0.9290)	0.92648 (0.0027)^a	-0.70135 (0.0162)^a
Nuclear pNF-κB	-0.18056 (0.6176)	0.71732 (0.0696)	0.41196 (0.2080)
Cytoplasmic pIKK	0.24608 (0.4931)	-0.21801 (0.6386)	-0.03438 (0.9201)

^aP < 0.05,

^bP < 0.001. HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; ER: Estrogen receptor; WTL: Whole tissue lysates.

Citation: Iyer JK, Kalra M, Kaul A, Payton ME, Kaul R. Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol 2017; 23(37): 6802-6816
URL: https://www.wjgnet.com/1007-9327/full/v23/i37/6802.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i37.6802