Copyright
©The Author(s) 2017.
World J Gastroenterol. Oct 7, 2017; 23(37): 6750-6776
Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6750
Published online Oct 7, 2017. doi: 10.3748/wjg.v23.i37.6750
Table 2 Studies tracing possible cells of origin of hepatocellular carcinoma
Cell | Tracing gene promoter | HCC models in mice | Tumor positive to lineage-traced | Ref. |
LSPCs | HNF1β | DEN 17 d postnatal | NO | [132] |
Mdr2KO | ||||
Foxl1 | DEN/CCl4 | NO | [131] | |
OPN | DEN 15 d postnatal | NO | [7] | |
DEN/CCl4 | ||||
K19 | DEN/CCl4 | NO | [7] | |
HybHPs + LSPCs | Sox9 | DEN | NO | [114] |
MUP-uPA/HFD | ||||
STAM | ||||
Hepatocytes (mature) | TBG | DEN/CCl4 | YES (approximately 100%) | [7,131] |
DEN/CDE | ||||
DEN/DDC | ||||
Mdr2KO | ||||
HSC | Lrat | DEN/CCl4 | NO | [7] |
Mdr2KO |
- Citation: Flores-Téllez TN, Villa-Treviño S, Piña-Vázquez C. Road to stemness in hepatocellular carcinoma. World J Gastroenterol 2017; 23(37): 6750-6776
- URL: https://www.wjgnet.com/1007-9327/full/v23/i37/6750.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i37.6750