Retrospective Cohort Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. Sep 28, 2017; 23(36): 6685-6693
Published online Sep 28, 2017. doi: 10.3748/wjg.v23.i36.6685
Table 2 Potential prognostic factors for disease-free survival and overall survival after radical resection for type IV hilar cholangiocarcinoma patients excluding operative mortality n (%)
VariableDisease-free survival
Overall survival
5-yr survivalUnivariate analysisMultivariate analysis
5-yr survivalUnivariate analysisMultivariate analysis
P valueHR (95%CI)P valueP valueHR (95%CI)P value
Gender0.6820.965
Male13 (18.8)14 (20.3)
Female10 (16.4)10 (16.4)
Age (yr)0.0391.291 (0.680-2.453)0.4350.230
< 6519 (19.2)20 (20.2)
> 654 (12.9)4 (12.9)
CA19-90.2870.301
< 20013 (23.2)14 (25)
> 20010 (13.5)10 (13.5)
ALB (g/L)0.0050.669 (0.413-1.085)0.1030.0090.760 (0.492-1.173)0.215
< 353 (7.1)3 (7.1)
> 3521 (23.9)20 (22.7)
Surgical method0.8470.684
Left-sided hepatectomy13 (15.1)13 (15.1)
Right-sided hepatectomy10 (17.2)11 (19.0)
Resection margin< 0.0016.255 (3.485-11.229)< 0.001< 0.0016.776 (3.988-11.479)< 0.001
Positive00
Negative23 (23.7)24 (24.7)
Histologic grade0.0231.594 (0.994-2.554)0.0530.0261.294 (0.830-2.017)0.256
Well/moderate20 (21.5)21 (22.6)
poor3 (8.1)
Perineural invasion0.2110.417
Present14 (22.6)15 (24.2)
Absent9 (13.2)9 (13.2)
T stage0.0041.582 (0.390-6.415)0.5210.0012.399 (0.734-7.836)0.147
T1/222 (22)21 (21)
T3/42 (6.7)2 (6.7)
N stage< 0.0012.902 (1.132-7.439)0.027< 0.0012.827 (1.243-6.429)0.013
N022 (27.2)23 (28.4)
N11 (2.0)1 (2.0)
AJCC stage< 0.0010.673 (0.289-1.567)0.358< 0.0010.844 (0.351-2.028)0.704
Stage I/II20 (32.8)21 (34.4)
Stage III/IV3 (4.9)3 (4.9)
Lymphovascular invasion< 0.0012.799 (1.588-4.935)< 0.001< 0.0012.908 (1.712-4.938)< 0.001
Present00.000
Absent23 (22.8)24 (24.8)
Tumor size (mm)< 0.0011.942 (1.176-3.209)0.010< 0.0011.739 (1.101-2.745)0.018
≤ 3015 (20)16 (21.3)
> 308 (14.5)8 (14.5)
Portal vein invasion0.0031.759 (0.534-5.800)0.3530.0021.130 (0.408-3.127)0.815
Present1 (4.2)1 (4.2)
Absent22 (20.8)23 (21.7)
Hepatic invasion0.0081.499 (0.612-3.668)0.3760.0131.196 (0.526-2.719)0.669
Present1 (9.1)1 (9.1)1 (9.1)
Absent22 (18.5)22 (18.5)23 (19.3)
Transfusion0.4450.199
Yes11 (16.4)11 (16.4)
No12 (19.0)13 (20.6)