Nonalcoholic fatty liver disease: Evolving paradigms

Table 2 Drugs useful in treating nonalcoholic steatohepatitis - A neck-to-neck comparison of findings from two different meta-analytic studies

	Sawangjit et al[244]	Singh et al[243]
Fibrosis	OCA1 improves fibrosis.PTX2, TZDs plus Metformin2, TZDs plus Losartan2 might potentially be effective.	PTX1 and OCA1 improve fibrosis
Resolution of NASH	TZDs1 and Vitamin E1 use is associated with resolution of NASH	Vitamin E1, TZDs1, and OCA1 improve ballooning degeneration
NAS	PTX1, OCA1, vitamin E1, and TZDs1 improve NAS
Steatosis		PTX1, Vitamin E2, TZD1 and OCA2 significantly improve steatosis
Lobular inflammation		PTX1, TZDs1 and OCA2 significantly improve lobular Inflammation

¹High quality of evidence;

²Moderate quality of evidence. NASH: Nonalcoholic steatohepatitis; NAS: NASH activity score; OCA: Obeticholic acid; PTX: Pentoxyphylline; TZDs: Thiazolidinediones.