Gastrosplenic fistula occurring in lymphoma patients: Systematic review with a new case of extranodal NK/T-cell lymphoma

Figure 4 Microscopic specimen of the spleen and stomach. A: Atypical lymphoma cells were found in the spleen on hematoxylin-eosin stain (left). These cells showed positivity for CD3 on immunohistochemistry stain (middle) and EBV on EBV RNA stain (right). There was also extensive coagulative necrosis indicative of splenic infarction; B: Lymphoma cells were found in the stomach wall near the gastrosplenic fistula on hematoxylin-eosin stain (left), and which also showed positivity for CD3 (middle) and EBV (right). NK/T-cell lymphoma was diagnosed. These findings suggested that lymphoma cells may have infiltrated from the spleen to the stomach wall through the perforation site. EBV: Epstein-Barr virus.