Moxibustion eases chronic inflammatory visceral pain through regulating MEK, ERK and CREB in rats

Figure 5 Comparison of expression of phospo-mitogen-activated extracellular signal-regulated kinase 1, phosphor-extracellular signal-regulated kinase 1/2 and cAMP response element binding protein in rat spinal cord. A: Protein expression of pMEK1; B: Protein expression of pERK1/2; C: Protein expression of pCREB. ^bP < 0.01 vs normal group; ^dP < 0.01 vs model group; ^fP < 0.01 vs sham-HPM group; ^hP < 0.01 vs DMSO group. pCREB: cAMP response element binding protein; DMSO: Dimethyl sulfoxide; pERK: Phosphor-extracellular signal-regulated kinase; HPM: Herb-partitioned moxibustion; pMEK1: Phospo-mitogen-activated extracellular signal-regulated kinase 1; NG: Normal group; MG: Model group; SHPMG: Sham-HPM group; MIG: MEK-inhibitor group; DG: Dimethyl sulfoxide group.