Access to biologicals in Crohn’s disease in ten European countries

Table 3 Affordability of biologicals - annual costs and annual costs (2016) as a percentage of gross domestic product per capita (2014)

	Cz	Fr	D	Hu	Lv	Pl	Ro	Sk	Es	Se
Annual total drug cost per patient (€)
Remicade	11925	13439	29081	15204	11202	10638	15469	12020	16591	16169
Remsima	11925	13439	23915	13694	11202	10638	12375	12020	12443	9157
Inflectra	11925	13439	22213	10674	11201	10638	12375	12020	12443	6841
Humira	11131	10625	24402	12326	14050	14800	24360	13697	12209	15286
Entyvio	-	-	24651	-	-	-	22275	20207	30218	19243
Annual cost, % of GDP (Affordability ratio)
Remicade	69%	36%	69%	124%	80%	84%	176%	74%	73%	31%
Remsima	69%	36%	57%	111%	80%	84%	141%	74%	55%	18%
Inflectra	69%	36%	53%	87%	80%	84%	141%	74%	55%	13%
Humira	65%	28%	58%	100%	101%	117%	277%	84%	54%	30%
Entyvio	-	-	59%	-	-	-	253%	124%	133%	37%
Average, without Entyvio	68%	34%	59%	106%	85%	92%	184%	77%	59%	23%
Average, all drugs	68%	34%	59%	106%	85%	92%	198%	86%	74%	26%

Annual total drug cost was calculated based on available list prices, and the EMA product information on the recommended drug dose and frequency. For infliximab we calculated with an average body weight of 75 kg. All costs were converted to Euros using the official exchange rate as of May 2016: 1 EUR= 27.025 CZK = 312.44 HUF = 4.3861 PLN = 9.2605 SEK. Cz: The Czech Republic; Fr: France; D: Germany; Hu: Hungary; Lv: Latvia; Pl: Poland; Ro: Romania; Sk: Slovakia; Es: Spain; Se: Sweden; GDP: Gross domestic product.