Access to biologicals in Crohn’s disease in ten European countries

Table 2 Clinical and administrative requirements of biological treatment (2016)

	Cz	Fr	D	Hu	Lv	Pl	Ro	Sk	Es	Se
Required level of disease activity (such as CDAI) or disease severity required for initiation of biological treatment
Not specified (0 point)	x		x		x				x	x
CDAI > 220 (1 point)							x	x
CDAI > 300 (2 points)		x		x		x
Required failure of /intolerance to non-biological treatment before a patient is eligible for a biological
Steroids (1 point)			x
Immunosuppressive (1 point)							x
Steroids OR immunosuppressive (1 point)	x	x							x	x
Steroids AND Immunosuppressive (2 points)				x	x	x		x
Other procedures required after the indication of a biological treatment
No other procedures (0 point)	x	x	x	x	x	x			x	x
Other requirements (e.g., approval or authorization by the health insurance fund) (1 point)							x	x
Approved centers necessary for a biological treatment
No restriction to approved centers (0 point)		x	x							x
Restriction to approved centers (1 point)	x			x	x	x	x	x	x
Specialists who may indicate and prescribe biologicals for the treatment of CD in adults
Gastroenterologist, immunologist and GP/other (0 point)			x							x
Gastroenterologist and immunologist (1 point)		x
Only gastroenterologist (2 points)	x			x	x	x	x	x	x
Total availability score (min 0 to max 8)	4	4	1	7	5	7	6	7	4	1

Cz: The Czech Republic; Fr: France; D: Germany; Hu: Hungary; Lv: Latvia; Pl: Poland; Ro: Romania; Sk: Slovakia; Es: Spain; Se: Sweden.