Access to biologicals in Crohn’s disease in ten European countries

Table 1 Clinical and reimbursement guidelines

Country	Guideline	Source, organization, last update, web-link
The Czech Republic	Clinical	Bortlík et al[25] 2016 by IBD Working Group of the Czech Society of Gastroenterology
	Reimbursement	Reimbursement criteria of the SUKL1; Edited by: SUKL, http://www.sukl.cz
France	Clinical	ECCO guidelines, Crohn's Disease Guidelines (2010), Check list ANTI TNF, Check list VEDOLIZUMAB by GETAID2https://www.getaid.org/recommandations.html
	Reimbursement	No
Germany	Clinical	German Guidelines on Crohn’s disease; DGVS German Society of Gastroenterology (2014)
	Reimbursement	No
Hungary	Clinical	Miheller et al[26] 2009
	Reimbursement	The diagnostic and treatment of Crohn’s disease] by NHIFA3 (2013) http://www.oep.hu/data/cms989735/0626_a_felnottkori_crohn_betegseg_diagnosztikajanak_es_kezelesenek_finanszirozasi_protokollja.pdf
Latvia	Clinical	No national guideline, but following the ECCO guideline
	Reimbursement	National Health Service of Latvia. No specific document, but part of the general regulations on medication reimbursement.(2016)
Poland	Clinical	[The treatment of Crohn’s Disease (ICD-10 K 50)], National Health Fund, (2014) http://onkologia-online.pl/upload/obwieszczenie/2015.10.28/b/b.32.pdf
	Reimbursement	No
Romania	Clinical	National Insurance Fund Protocol (2013) http://www.cnas.ro/default/index/index/lang/EN
	Reimbursement	National Insurance Fund protocol (2013) http://www.cnas.ro/default/index/index/lang/EN
Slovakia	Clinical	No national guideline, but following the ECCO guideline
	Reimbursement	Protocol for starting and continuing the biological treatment. Date first approvals: infliximab 2005, adalimumab 2008, vedolizumab 2016; The Slovakian Gastroenterology Association and The Union of Health Insurance Companies.
Spain	Clinical	Guidelines for biologics by GETECCU4 (2013) http://geteccu.org/formacion/guias-y-documentos-de-consenso; Cabriada et al[27] 2013
	Reimbursement	No
Sweden	Clinical	(1) National Guidelines for the treatment of Crohn’s disease; The Swedish Society of Gastroenterology (2017) http://www.svenskgastroenterologi.se/sites/default/files/pagefiles/Riktlinjer_Lakemedelsbehandling_vid_Crohns_2012.pdf
		(2) The use of IFX biosimilar in patients with IBD; Swedish Society of Gastroenterology (2017) http://www.svenskgastroenterologi.se/sites/default/files/pagefiles/SGF_riktlinjer_Biosimilarer_150903.pdf
		(3) The Medical Product Agency: Drug treatment of IBD, novel recommendations by the Medical Product Agency, Sweden (2012) https://lakemedelsverket.se/upload/halso-och-sjukvard/behandlingsrekommendationer/L%C3%A4kemedelsbehandling%20vid%20inflammatorisk%20tarmsjukdom%20-%20ny%20rekommendation_bokm%C3%A4rken.pdf
	Reimbursement	No

¹State Institute for Drug Control;

²Groupe d'Étude Thérapeutique des Affections Inflammatoires du Tube Digestif;

³National Health Insurance Fund Administration;

⁴Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa.