Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats

doi:10.3748/wjg.v23.i34.6231

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 14, 2017; 23(34): 6231-6241
Published online Sep 14, 2017. doi: 10.3748/wjg.v23.i34.6231

Table 4 Hypothalamic mRNA expression of preproghrelin, ghrelin O-acyltransferase and neuropeptide Y

X-mRNA/β-acting-mRNA	S0	SG
Preproghrelin	0.63 ± 0.12	0.50 ± 0.11^a
GOAT	0.96 ± 0.09	0.87 ± 0.08^a
NPY	0.61 ± 0.04	0.65 ± 0.07

Hypothalamic mRNA expression of preproghrelin, GOAT and NPY was quantified using PCR and expressed as the ratio to the β-actin mRNA. Statistical differences between the two groups were analyzed using Student’s t test.

^aP < 0.05, S0 vs SG. GOAT: Ghrelin O-acyltransferase; SG: Sleeve gastrectomy; NPY: Neuropeptide Y.

Citation: Wang Q, Tang W, Rao WS, Song X, Shan CX, Zhang W. Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats. World J Gastroenterol 2017; 23(34): 6231-6241
URL: https://www.wjgnet.com/1007-9327/full/v23/i34/6231.htm
DOI: https://dx.doi.org/10.3748/wjg.v23.i34.6231