Changes of Ghrelin/GOAT axis and mTOR pathway in the hypothalamus after sleeve gastrectomy in obese type-2 diabetes rats

Table 2 Oral glucose tolerance test of blood glucose

Time points (min)	Blood glucose (mmol/L)
	First day			Preoperative			Postoperative
	S0	Sh	SG	S0	Sh	SG	S0	Sh	SG
0	6.18 ± 1.19	5.89 ± 1.12	6.19 ± 0.94	15.03 ± 2.40a	15.90 ± 1.20a	15.88 ± 2.32a	14.55 ± 1.29	14.29 ± 1.69	9.00 ± 1.17ce
15	6.18 ± 1.17	6.42 ± 1.22	6.66 ± 1.27	20.82 ± 3.80a	21.35 ± 4.13a	20.84 ± 4.41a	19.06 ± 2.68	18.39 ± 2.42	10.12 ± 1.07ce
30	7.15 ± 1.03	7.13 ± 1.27	7.03 ± 1.32	21.76 ± 3.45a	22.13 ± 2.96a	21.15 ± 2.86a	20.09 ± 4.02	22.47 ± 3.63	11.21 ± 1.02ce
60	7.22 ± 1.36	7.07 ± 1.38	6.93 ± 1.02	22.23 ± 3.47a	22.23 ± 4.03a	22.96 ± 2.78a	20.32 ± 3.26	19.80 ± 3.49	11.75 ± 0.95ce
90	6.45 ± 1.21	6.27 ± 1.31	6.58 ± 1.31	17.72 ± 2.19a	18.48 ± 2.54a	17.43 ± 2.61a	18.30 ± 2.50	18.81 ± 2.90	8.76 ± 1.01ce
120	6.00 ± 0.92	5.89 ± 0.65	5.58 ± 0.75	15.47 ± 1.55a	15.04 ± 1.58a	15.67 ± 1.44a	14.08 ± 1.00	15.07 ± 1.63	6.98 ± 1.13ce

Statistical differences among the three groups were analyzed by one-way ANOVA followed by LSD-t test and between two time points in one group using a paired t test.

^aP < 0.05, preoperative vs first day levels in the same group at the same time point;

^cP < 0.05, postoperative vs preoperative levels in the SG group;

^eP < 0.05, SG vs S0 and Sh postoperatively. LSD: Least significant difference; Sh: Sham operation group; SG: Sleeve gastrectomy.