Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer

Table 4 Colorectal cancer specific mortality and the association with highest tertile level of inflammatory factors

Factor	CRC specific mortality		CRC specific mortality adjusted1
	HR (95%CI)	P value	HR (95%CI)	P value
Age	1.0 (1.0-1.0)	0.532	1.1 (1.0-1.1)	0.006
TNM stage II	0.7 (0.1-4.1)	0.674	0.5 (0.1-3.0)	0.444
TNM stage III	2.6 (0.6-11.7)	0.201	2.7 (0.6-12.9)	0.209
TNM stage IV	15.5 (3.6-66.3)	< 0.001	27.6 (5.8-131.1)	< 0.001
Radical surgery	0.2 (0.1-0.5)	0.001	0.19 (0.1-0.5)	0.001
Preoperative treatment	0.5 (0.2-1.2)	0.106	0.4 (0.1-0.9)	0.359
Adjuvant treatment	2.2 (1.2-4.2)	0.013	0.9 (0.5-2.0)	0.947
CCL1	3.2 (1.4-7.0)	0.004	2.8 (1.1-7.1)	0.025
CCL3	2.4 (1.1-5.3)	0.036	1.2 (0.5-2.8)	0.653
CCL15	2.8 (1.3-6.1)	0.011	2.0 (0.9-4.9)	0.107
CCL20	4.0 (1.6-10.1)	0.003	2.7 (1.0-7.0)	0.046
CCL24	2.2 (1.0-4.8)	0.061	2.5 (1.1-5.7)	0.037
CX3CL1	3.7 (1.6-8.3)	0.002	2.6 (1.1-6.4)	0.036
CXCL16	2.5 (1.1-5.4)	0.022	2.0 (0.8-4.8)	0.138
IFN-γ	1.8 (0.8-3.9)	0.138	1.7 (0.7-4.1)	0.253
IL-1β	1.9 (0.9-3.8)	0.090	1.7 (0.8-3.6)	0.193
IL-4	2.5 (1.1-5.7)	0.033	2.4 (1.0-5.5)	0.048
IL-8/CXCL8	3.3 (1.5-7.3)	0.003	1.5 (0.6-3.5)	0.344
TNF-α	2.0 (0.9-4.2)	0.078	2.3 (1.0-5.4)	0.047

¹When adjusted for age, TNM stage, radical surgery, preoperative- and adjuvant treatment. CRC: Colorectal cancer.