Editorial
Copyright ©The Author(s) 2017.
World J Gastroenterol. Sep 14, 2017; 23(34): 6197-6200
Published online Sep 14, 2017. doi: 10.3748/wjg.v23.i34.6197
Table 1 Long-term outcomes of patients with perianal fistulizing Crohn’s disease on anti-tumor necrosis factor maintenance therapy
Type of anti-TNF therapynComplex fistulas, %Follow up, wkTherapeutic outcome of interestTherapeutic outcome, %Ref.
IFX687552Complete fistula closure & CDAI < 15034[4]
IFX5985> 56Complete fistula closure (PGA)41[5]
IFX13ND951Reduction of fistulas number (MRI)15[5]
IFX156822501At least 1 fistula closure69[6]
IFX12ND156Clinical remission (PGA)33[7]
IFX12ND156Radiological healing (MRI)42[7]
IFX19ND52Absence of draining fistulas (PGA)53[8]
IFX26692552Complete fistula closure42[9]
IFX (RCT)96ND54Complete fistula closure36[10]
IFX/ADM49ND1602Deep remission (PGA, MRI, endoscopy)33[11]
IFX/ADM49ND1602Absence of draining fistulas (PGA)53[11]
IFX/ADM20ND52Absence of draining fistulas (PGA)35[12]
IFX/ADM78671921Absence of drainage with seton removal53[13]
IFX/ADM20ND78Radiological healing (MRI)30[8]
ADM7ND156Absence of draining fistulas (PGA)0[7]
ADM7ND156Radiological healing (MRI)14[7]
ADM7ND52Absence of draining fistulas (PGA)29[8]
ADM39ND52Clinical remission (FDAI)41[14]
ADM14ND52Radiological healing (MRI)43[14]
ADM53ND40Complete fistula closure41[15]
ADM (RCT)70ND56Absence of draining fistulas (PGA)33[16]
ADM (post hoc)70ND116Absence of draining fistulas (PGA)31[17]
CZP (RCT)28ND26Complete fistula closure36[18]