Ca2+/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways

Figure 3 CaMKII regulates colon cancer cells proliferation and migration via ERK1/2- and p38-dependent pathways. Human colon cancer cells HCT116 were treated with or without PD98059 (50 μmol/L) or SB203580 (10 μmol/L) for 24 h. A: MTT assay for cell proliferation; B: Western blot analysis of ERK1/2, phosphor-ERK1/2, p38 and phosphor-p38; C: Immigration and invasion analysis by T transwell assay. All data are presented as the mean ± standard error SE of at least three independent experiments. ^aP < 0.05, vs control group.