Ca2+/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways

Figure 2 CaMKII is required for colon cancer proliferation and migration. Human colon cancer cells HCT116 were treated with or without KN93 or KN92 at 10 μmol/L for 24 h. A: MTT analysis for cell proliferation; B: Western blot of MMP2, MMP9 and TIMP-1; C: qRT-PCR assay of MMP2, MMP9 and TIMP-1; D: Immigration and invasion analysis by T transwell assay; E: Wound-healing test. All data are presented as the mean ± standard error SE of at least three independent experiments. ^aP < 0.05, ^bP < 0.01 vs control group.