Ca2+/calmodulin-dependent protein kinase II regulates colon cancer proliferation and migration via ERK1/2 and p38 pathways

Figure 1 CaMKII over-expressed in colon cancer. A: Immunochemistry staining of CaMKII in paracancerous tissue, well-differentiated colon cancer and poorly differentiated colon cancer samples. Scale bar, 100 μm; B: qRT-PCR of CaMKII mRNA in paraffin-embedded paracancerous tissue, well-differentiated colon cancer and poorly differentiated colon cancer samples; C: Western blot of CaMKII protein in paraffin-embedded paracancerous tissue, well-differentiated colon cancer and poorly differentiated colon cancer samples. All data are presented as the mean ± standard error of at least three independent experiments. ^aP < 0.05, ^bP < 0.01 vs paracancerous tissue.