High yield reproducible rat model recapitulating human Barrett’s carcinogenesis

Figure 2 Diagram of modified Levrat model and images of the main steps of the surgical procedure. A: Illustration of end-to-side esophagojejunostomy with gastric preservation; B: Esophagus is mobilized, preserving the left and right vagus nerves; C: Esophagus divided from the stomach after ligation of gastroesophageal junction; D: Anterior esophageal suture placed through muscle and mucosa layers, allowing proper visualization of mucosa; E: Anterior and lateral esophageal sutures intact, creating visualization of the lumen; F: Completed anastomosis between the distal esophagus and jejunum with eight interrupted full-thickness sutures; G: Anastomosis returned to anatomical location wrapped in omentum.