Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity

Figure 7 Effect of compound administration on von Frey threshold in naïve mice. A: The non-selective ASIC blocker amiloride significantly decreased abdominal threshold in mice 4 and 24-h post-administration when dosed at 30 mg/kg. B: Linaclotide, asimadoline and carbamazepine significantly decreased abdominal threshold in mice 4-h post-administration. Data are expressed as the mean ± SEM, where n = 9-10 mice/group. ^aP < 0.05 vs vehicle.