Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity

Figure 3 Effect of transient receptor potential channel blockade on gastric ulcer pain. A: Dose-response and time course efficacy for selective TRPV1 channel blockade on referred gastric ulcer pain. AMG 9810 significantly attenuated referred gastric ulcer pain when dosed at 30 mg/kg; B: Dose-response and time course for the effect of selective TRPA1 channel blockade on referred gastric ulcer pain. HC-030031 significantly attenuated referred gastric ulcer pain when dosed at 300 mg/kg. All data are expressed as the mean SEM where n = 10 mice/group. ^aP < 0.05 vs vehicle, ^cP < 0.05 vs indomethacin.