Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity

Figure 2 Effect of opioid receptor agonism on gastric ulcer pain. A: Dose-response and time course for the effect of a mu opioid receptor agonist on referred gastric ulcer pain. Morphine significantly attenuated referred gastric ulcer pain when dosed 10-30 mg/kg; B: Dose-response and time course for the effect of a selective kappa opioid receptor agonist on referred gastric ulcer pain. Asimadoline significantly attenuated referred gastric ulcer pain when dosed 10-30 mg/kg. All data are expressed as the mean ± SEM, where n = 8-10 mice/group. ^aP < 0.05 vs vehicle, ^cP < 0.05 vs indomethacin.