Changes with aging in gastric biomarkers levels and in biochemical factors associated with Helicobacter pylori infection in asymptomatic Chinese population

Table 3 Comparison of serum gastric biomarker levels and biochemical tests in various age groups by Helicobacter pylori infection status

	35-44 yr	45-54 yr	55-64 yr	65-74 yr	≥ 75 yr	F	P value
	n1 = 21	n1 = 39	n1 = 57	n1 = 36	n1 = 33
	n2 = 37	n2 = 45	n2 = 60	n2 = 40	n2 = 27
PGI, μg/L
Hp-IgG (+)	89.43 ± 7.46	100.03 ± 6.45	90.25 ± 5.10	92.61 ± 12.23	94.95 ± 13.47	0.824	0.920
Hp-IgG (-)	83.6 ± 6.47	81.28 ± 3.89	83.96 ± 5.04	96.67 ± 10.31	105.49 ± 8.08	1.730	0.143
PGII, μg/L
Hp-IgG (+)	14.68 ± 1.08	18.45 ± 1.34	17.47 ± 1.16	19.52 ± 1.46	19.51 ± 1.91	1.393	0.260
Hp-IgG (-)	6.80 ± 0.58	6.89 ± 0.41	7.64 ± 0.46	9.46 ± 1.42	10.23 ± 0.761b2b	1.115	0.011
PGI/PGII
Hp-IgG (+)	7.92 ± 0.53	7.17 ± 0.39	7.03 ± 0.38	6.65 ± 0.58	6.97 ± 0.52	0.662	0.616
Hp-IgG (-)	12.66 ± 0.41	12.25 ± 0.42	12.18 ± 0.39	11.68 ± 0.89	10.85 ± 0.80	1.163	0.353
G-17, pmol/L
Hp-IgG (+)	4.11 ± 0.74	9.81 ± 2.58	8.18 ± 2.17	7.16 ± 0.95	13.7 ± 4.79	1.258	0.285
Hp-IgG (-)	2.26 ± 0.73	1.02 ± 0.26	3.44 ± 2.03	12.43 ± 5.65	5.54 ± 3.90	2.254	0.066
TC, mmol/L
Hp-IgG (+)	4.42 ± 0.14	4.96 ± 0.14	5.30 ± 0.111b	5.51 ± 0.191b	5.00 ± 0.15	6.604	< 0.001
Hp-IgG (-)	4.77 ± 0.10	5.41 ± 0.171a	5.35 ± 0.131a	5.18 ± 0.16	4.98 ± 0.14	2.709	0.031
LDL-C, mmol/L
Hp-IgG (+)	2.71 ± 0.14	3.10 ± 0.12	3.40 ± 0.111a	3.60 ± 0.171b2a	3.17 ± 0.14	7.291	< 0.001
Hp-IgG (-)	2.89 ± 0.09	3.47 ± 0.151a	3.48 ± 0.111b	3.33 ± 0.13	3.08 ± 0.13	3.544	0.008
FBG, mmol/L
Hp-IgG (+)	5.25 ± 0.08	5.22 ± 0.13	5.38 ± 0.12	5.46 ± 0.12	5.44 ± 0.08	0.791	0.532
Hp-IgG (-)	5.01 ± 0.06	5.21 ± 0.08	5.29 ± 0.08	5.34 ± 0.08	5.39 ± 0.34	1.186	0.318
Cr, μmol/L
Hp-IgG (+)	56.95 ± 2.57	60.38 ± 2.35	63.79 ± 1.71	63.61 ± 3.04	81.4 ± 7.241a	4.974	0.001
Hp-IgG (-)	59.19 ± 2.05	62.78 ± 1.95	61.20 ± 1.67	63.53 ± 2.29	73.19 ± 3.401b2a3b	4.174	0.003
Cys-C, mg/dL
Hp-IgG (+)	0.69 ± 0.02	0.78 ± 0.021a	0.84 ± 0.021b	0.97 ± 0.031b2b3a	1.19 ± 0.071b2b3b	19.952	< 0.001
Hp-IgG (-)	0.71 ± 0.02	0.78 ± 0.02	0.83 ± 0.021b	0.93 ± 0.031b2b	1.14 ± 0.041b2b3b4b	28.435	< 0.001

Data are presented as mean ± SD. Hp-IgG (+) is defined as Hp-IgG ≥ 35 EIU. n1: number in the Hp-IgG (+) group; n2: number in the Hp-IgG(-) group.

¹35-44-years-old group,

²45-54-years-old group,

³55-64-years-old group,

⁴65-74-years-old group,

^aP < 0.05,

^bP < 0.01. Cr: Creatinine; Cys-C: Cystatin-C; FBG: Fasting blood glucose; G-17: Gastrin-17; Hp-IgG: Helicobacter pylori-immunoglobulin G; LDL-C: Low-density lipoprotein cholesterol; PGI: Pepsinogen I; PGII: Pepsinogen II; TC: Total cholesterol.