Novel predictors for lymph node metastasis in submucosal invasive colorectal carcinoma

Table 3 Comparison of histopathological factors for predicting of lymph node metastasis by multivariate analysis

Model	AUC	SE	95%CI	Difference AUC	95%CI	P value
Crude (unadjusted)	0.640	0.046	(0.549, 0.730)
JSCCR (depth)	0.666	0.041	(0.585, 0.747)	0.026	(0.009, 0.043)	0.0022
Kitajima (depth)	0.650	0.044	(0.565, 0.736)	0.011	(-0.022, 0.043)	0.5103
Ueno (depth)	0.664	0.042	(0.582, 0.746)	0.024	(0.009, 0.040)	0.0024
Width	0.692	0.040	(0.613, 0.771)	0.053	(-0.007, 0.112)	0.0829
JSCCR (depth × width)	0.703	0.038	(0.629, 0.776)	0.063	(0.024, 0.103)	0.0017
Kitajima (depth × width)	0.681	0.042	(0.599, 0.763)	0.042	(-0.002, 0.085)	0.0612
Ueno (depth × width)	0.699	0.038	(0.624, 0.775)	0.060	(0.020, 0.099)	0.0030
Budding (ueno)	0.768	0.044	(0.682, 0.853)	0.128	(0.043, 0.214)	0.0033
Lymphatic invasion	0.843	0.041	(0.763, 0.924)	0.204	(0.114, 0.294)	< 0.0001
Budding present itself	0.830	0.0277	(0.776, 0.884)	0.190	(0.106, 0.274)	< 0.0001
PDCs	0.811	0.0296	(0.753, 0.870)	0.172	(0.087, 0.256)	< 0.0001

Crude: Tumor type, desmoplasia each model was adjusted to the tumor type and desmoplasia. AUC: Area under curve; JSCCR: Japanese Society for Cancer of the Colon and Rectum; PDCs: Poorly differentiated clusters.