Copyright
©The Author(s) 2017.
World J Gastroenterol. Aug 28, 2017; 23(32): 5913-5924
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5913
Published online Aug 28, 2017. doi: 10.3748/wjg.v23.i32.5913
Table 4 Risk groups of thymidylate synthase polymorphisms
| Group | Relapsed | De novo metastatic | Total |
| TYMS 5’UTR | |||
| Low expression | |||
| 2RG | 2 (4.2) | 6 (14.6) | 8 (9.0) |
| 2RG/3RC | 8 (16.7) | 3 (7.3) | 11 (12.4) |
| 3RC | 6 (12.5) | 5 (12.2) | 11 (12.4) |
| Medium expression | |||
| 2RG/3RG | 4 (8.3) | 4 (9.8) | 8 (9) |
| 2RG/3RCLOH | 7 (14.6) | 3 (7.3) | 10 (11.2) |
| 2RG/3RGLOH | 3 (6.3) | 2 (4.9) | 5 (5.6) |
| 2RGLOH/3RC | 1 (2.1) | 2 (4.9) | 3 (3.4) |
| High expression | |||
| 3RG | 4 (8.3) | 4 (9.8) | 8 (9.0) |
| 3RG/3RC | 9 (18.8) | 8 (19.5) | 17 (19.1) |
| 2RGLOH/3RG | 4 (8.3) | 4 (9.8) | 8 (9.0) |
| TYMS 3’UTR | |||
| Low expression | |||
| del/del | 6 (12.5) | 7 (17.1) | 13 (14.6) |
| Medium expression | |||
| ins/del | 19 (39.6) | 10 (24.4) | 29 (32.6) |
| del/LOH | 1 (2.1) | 3 (7.3) | 4 (4.5) |
| High expression | |||
| ins/ins | 8 (16.7) | 13 (31.7) | 21 (23.6) |
| ins/LOH | 14 (29.2) | 8 (19.5) | 22 (24.7) |
- Citation: Ntavatzikos A, Spathis A, Patapis P, Machairas N, Peros G, Konstantoudakis S, Leventakou D, Panayiotides IG, Karakitsos P, Koumarianou A. Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer. World J Gastroenterol 2017; 23(32): 5913-5924
- URL: https://www.wjgnet.com/1007-9327/full/v23/i32/5913.htm
- DOI: https://dx.doi.org/10.3748/wjg.v23.i32.5913