Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis

Table 2 Impact of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten on liver function in rat liver fibrosis induced by CCl₄ in treatment groups at different time points

Group	ALT (U/L)	AST (U/L)	ALB (g/L)	TBIL (μmol/L)	DBIL (μmol/L)
Tre 1 wk
Control	57.78 ± 8.23	146.78 ± 12.23	27.99 ± 1.18	2.49 ± 0.55	1.65 ± 0.36
CCl4	684.32 ± 78.34	840.32 ± 32.25	25.26 ± 3.25	15.45 ± 3.23	6.56 ± 1.12
Ad-GFP	645.65 ± 34.26	832.12 ± 40.32	24.54 ± 1.21	14.31 ± 1.21	7.21 ± 2.12
Ad-PTEN	384.98 ± 36.23b	398.43 ± 43.23b	27.60 ± 2.34b	11.21 ± 1.21b	5.32 ± 1.46b
Ad-G129E	495.34 ± 45.12b	546.32 ± 32.12b	26.12 ± 2.43	13.23 ± 2.12	7.86 ± 1.23b
PTEN shRNA	2030.31 ± 112.34a	1730.54 ± 87.34a	24.12 ± 2.34a	34.21 ± 5.34a	17.23 ± 2.12a
Tre 2 wk
Control	57.46 ± 3.58	142.34 ± 10.24	29.15 ± 3.21	2.68 ± 0.74	1.55 ± 0.46
CCl4	712.34 ± 34.54	843.23 ± 54.32	26.32 ± 1.34	14.32 ± 5.32	8.32 ± 2.12
Ad-GFP	697.45 ± 45.76	876.34 ± 33.32	25.79 ± 2.32	13.34 ± 2.13	7.86 ± 1.23
Ad-PTEN	338.12 ± 12.34b	407.34 ± 32.12b	27.56 ± 3.23b	6.56 ± 1.21b	3.72 ± 0.78b
Ad-G129E	364.32 ± 34.56b	408.67 ± 23.78b	27.21 ± 1.22b	10.32 ± 1.21b	5.34 ± 1.09b
PTEN shRNA	2040.21 ± 126.32a	1860.32 ± 210.32a	25.60 ± 3.12a	27.12 ± 4.21a	14.78 ± 2.12a
Tre 3 wk
Control	58.54 ± 6.58	148.45 ± 13.27	29.12 ± 3.15	2.12 ± 0.21	1.48 ± 0.24
CCl4	1892.32 ± 113.12	2018.32 ± 123.45	22.14 ± 1.23	8.18 ± 1.10	5.21 ± 0.65
Ad-GFP	1746.32 ± 98.23	1879.23 ± 119.34	23.10 ± 2.13	9.12 ± 1.23	5.72 ± 0.54
Ad-PTEN	524.35 ± 34.12b	690.35 ± 54.23b	27.30 ± 3.21b	6.45 ± 0.32b	4.12 ± 0.54b
Ad-G129E	576.23 ± 43.21b	820.43 ± 67.32b	25.20 ± 1.21b	8.12 ± 0.87b	4.89 ± 0.81b
PTEN shRNA	1937.56 ± 32.21a	2390.32 ± 112.23a	21.34 ± 2.34a	10.76 ± 1.23a	6.10 ± 0.54a
Tre 4 wk
Control	62.31 ± 8.12	155.37 ± 13.27	29.91 ± 3.12	2.49 ± 0.32	1.65 ± 0.21
CCl4	594.39 ± 32.18	1110.32 ± 89.34	23.45 ± 2.12	17.32 ± 2.32	9.28 ± 1.23
Ad-GFP	576.45 ± 23.43	886.43 ± 45.67	22.79 ± 1.21	13.45 ± 2.45	7.12 ± 1.34
Ad-PTEN	490.32 ± 32.23b	528.34 ± 32.12b	25.31 ± 3.21b	7.34 ± 1.21b	4.65 ± 0.98b
Ad-G129E	530.23 ± 22.56b	628.43 ± 45.34b	25.12 ± 1.23b	10.54 ± 2.32b	6.54 ± 1.21b
PTEN shRNA	1148.32 ± 54.32a	1270.34 ± 121.28a	20.37 ± 3.12a	26.32 ± 3.56a	14.56 ± 2.13a

Data are presented as mean ± SD for n = 3.

^aP < 0.05 vs CCl₄, Ad-GFP, Ad-PTEN;

^bP < 0.01 vs CCl₄, Ad-GFP. ALB: Albumin; ALT: Alanine transaminase; AST: Aspartate transaminase; DBIL: Direct bilirubin; PTEN: Phosphatase and tension homologue deleted on chromosome ten; TBIL: Total bilirubin.