Long non-coding RNAs in hepatocellular carcinoma: Potential roles and clinical implications

Table 1 Hepatocellular carcinoma associated long non-coding RNAs in this review

LncRNA	Chromosomal location	Dysregulation	Biological roles	Ref.
H19	11p15.5	Up-regulated	Promotes HCC growth	Matouk et al[93]
		Down-regulated	Inhibits migration and invasion of HCC cells	Lv et al[98]
HOTAIR	12q13.13	Up-regulated	Promotes HCC growth	Geng et al[107]
HOTTIP	7p15.2	Up-regulated	Promotes proliferation of HCC cells	Quagliata et al[115]
HULC	6p24.3	Up-regulated	Promotes HCC growth	Zhang et al[127]
MALAT1	11q 13.1	Up-regulated	Promotes invasion	Lai et al[148]
MVIH	10q22-q23	Up-regulated	Promotes HCC growth, microvascular invasion, and intrahepatic metastasis	Shi et al[153]
MEG3	14q32.2	Down-regulated	Inhibits cell growth	Zhu et al[166]
Lnc-FTX	Xq13.2	Up-regulated	Promotes proliferation and cell cycle progression of HCC cells	Liu et al[175]
		Down-regulated	Inhibits proliferation and cell cycle progression of HCC cells	Liu et al[176]

HCC: Hepatocellular carcinoma; LncRNA: Long non-coding RNA; H19: H19, imprinted maternally expressed transcript; HOTAIR: HOX antisense intergenic RNA; HOTTIP: HOXA transcript at the distal tip; HULC: Highly up-regulated in liver cancer; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; MEG3: Maternally expressed gene 3; MVIH: Microvascular invasion in HCC; FTX: Five prime to Xist.