Schistosoma japonicum attenuates dextran sodium sulfate-induced colitis in mice via reduction of endoplasmic reticulum stress

Figure 3 Administration of S. japonicum leads to lowered inflammatory cytokines in dextran sodium sulfate-induced colitis mice. A: The production of IL-2, IL-6, IL-10, IL-17A, TNFα and IFN-γ in blood samples was detected by CBA and flow cytometry; B: IL-1β, IL-6, IL-10, IL-17a, IFN-γ, TNFα and TGFβ levels in colon tissues were tested by RT-PCR. n = 3 or 4. Exposure to S. japonicum protected mice from DSS-induced colitis with down-regulation of the Th1/Th2/Th17 pathway. DSS: Dextran sodium sulfate treatment alone; CER + DSS: Infection with S. japonicum before DSS treatment; CER: S. japonicum infection alone.