Cytoplasmic domain of tissue factor promotes liver fibrosis in mice

Figure 1 Hepatic fibrosis area. Wildtype control mice administered vehicle alone showed minimal fibrosis (A). Compared to CCl₄ treated wild-type mice (B), hepatic fibrosis area was significantly lower in the PAR-2^-/- (C), TF^§CT/§CT (D) and TF^§CT/§CT/PAR-2^-/- (E) mice after CCl₄ exposure for 8 wk. (^bP < 0.01, ^cP < 0.001 ^dP < 0.0001).