Expression of Interleukin-26 is upregulated in inflammatory bowel disease

Figure 1 Expression of interleukin-26 mRNA in the inflamed mucosa of patients with inflammatory bowel disease. Total RNA was extracted from biopsied samples, and the mRNA expression of IL-26 was evaluated using real-time PCR. IL-26 mRNA expression was converted to a value relative to β-actin mRNA expression and presented as fold-increase relative to the results for normal mucosa. Data are expressed as mean ± SE. Normal mucosa, n = 20; active UC, n = 26; inactive UC, n = 23; active CD, n = 9; inactive CD, n = 10. ^aP < 0.05 UC active vs UC inactive, ^bP < 0.01 Normal vs UC active, Normal vs UC inactive, Normal vs CD active, UC active vs CD active, CD active vs CD inactive. IL: Interleukin; CD: Crohn’s disease; UC: Ulcerative colitis.