Mucosa-associated lymphoid tissue lymphoma with unusual 18F-FDG hypermetabolism arising at the colorectal anastomosis

Figure 8 Initiation of mucosa-associated lymphoid tissue lymphomagenesis. Continuous stimulation by pathogens leads to dense proliferation of clonal B cells, with the help of T-cell-dependent co-stimulation via CD40-CD40L and overexpression of B-cell-activating factors. The proliferative B cells undergo MALT lymphomagenesis through BCR-dependent NF-κB pathway, or BCR-independent NF-κB pathway characterized by chromosomal translocation.