Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage III and IV colorectal cancer

Table 5 Prognostic factors by multivariate Cox regression analysis (Stage III and IV)

Predictor	OS			DFS
	HR	95%CI	P value	HR	95%CI	P value
Age
< 60 yr	1.00			1.00
≥ 60 yr	1.46	1.13-1.89	0.004	1.10	0.84-1.44	0.479
Histology
Well/Moderate differentiated	1.00			1.00
Poorly differentiated	1.90	1.36-2.66	< 0.001	1.46	0.98-2.14	0.058
T stage
T1/T2	1.00			1.00
T3/T4	2.61	1.51-4.51	0.001	3.13	1.69-5.78	< 0.001
Lymphatic invasion
No	1.00			1.00
Yes	1.19	0.91-1.58	0.199	1.17	0.87-1.57	0.298
Vascular invasion
No	1.00			1.00
Yes	1.52	1.15-2.01	0.003	1.39	1.03-1.87	0.031
Peri-neural invasion
No	1.00			1.00
Yes	1.45	1.10-1.91	0.008	1.56	1.16-2.08	0.003
NLR
Low NLR (< 3.0)	1.00			1.00
High NLR (≥ 3.0)	1.44	1.14-1.83	0.003	1.43	1.11-1.85	0.005
PLR
Low PLR (< 160)	1.00			1.00
High PLR (≥ 160)	1.35	1.06-1.73	0.017	1.32	1.02-1.69	0.034

NLR: Neutrophil-to-lymphocyte-ratio; PLR: Platelet-to-lymphocyte-ratio; OS: Overall survival; DFS: Disease free survival.