Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage III and IV colorectal cancer

Table 4 Prognostic factors by multivariate Cox regression analysis (Stage I and II)

Predictor	OS			DFS
	HR	95%CI	P value	HR	95%CI	P value
Age
< 60 yr	1.00			1.00
≥ 60 yr	1.72	1.08-2.76	0.023	1.44	0.91-2.28	0.123
Histology
Well/moderate differentiated	1.00			1.00
Poorly differentiated	1.57	0.72-3.47	0.260	2.46	1.25-4.81	0.009
T stage
T1/T2	1.00			1.00
T3/T4	1.66	0.95-2.90	0.074	1.62	0.94-2.80	0.084
Lymphatic invasion
No	1.00			1.00
Yes	0.77	0.46-1.28	0.306	1.02	0.62-1.68	0.931
Vascular invasion
No	1.00			1.00
Yes	2.36	1.46-3.84	< 0.001	1.11	0.64-1.95	0.708
Peri-neural invasion
No	1.00			1.00
Yes	2.64	1.59-4.35	< 0.001	3.08	1.86-5.09	< 0.001
NLR
Low NLR (< 3.0)	1.00			1.00
High NLR (≥ 3.0)	1.16	0.76-1.76	0.498	1.06	0.69-1.62	0.788
PLR
Low PLR (< 160)	1.00			1.00
High PLR (≥ 160)	1.07	0.71-1.62	0.744	0.98	0.64-1.49	0.908

NLR: Neutrophil-to-lymphocyte-ratio; PLR: Platelet-to-lymphocyte-ratio; OS: Overall survival; DFS: Disease free survival.